Among them are Jack Tait, 18, from Highams Park School in Chingford, who has been offered a place at Princeton in New Jersey. He will be the first in his family to attend university.
Kerry O’Neil, 17, from Notre Dame High School in Glasgow, will also be the first in her family when she attends the University of Pennsylvania.
In total, the 43 have won places at 28 different institutions via the early admissions deadline, including four at Havard, four at Princeton and two at Yale.
More UK students will be applying by the regular January deadlines, with results available later this spring.
The Sutton Trust’s US Programme is run in conjunction with the US-UK Fulbright Commission – a not-for-profit organisation funded by both governments to promote educational exchange between the US and the UK.
Just over half of the students admitted early are from households that earn less than £25,000 a year, and 86 per cent will be among the first in their family to go to university.
The initiative also offers a summer school in the US for British students.
Last year, 150 students were selected for the summer school at either Yale University or the Massachusetts Institute of Technology (MIT), spending a week living on campus and visiting a number of other US campuses.
Sir Peter Lampl, chairman of the Sutton Trust, said: “Our US Programme is a life-changing experience so I’m delighted that so many young people from low and middle income backgrounds have benefited from it this year.
“The 43 talented students will enjoy a broad and varied curriculum and, with generous financial aid packages on offer, will graduate from some of the world’s best universities debt-free.
“I hope more young people will look to their success and realise that a university education in America is well within
their grasp.”
Applications for this year’s US Programme close on Wednesday (January 20), and can be completed online at http://us.suttontrust.com